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Acute oral toxicity and anti-inflammatory activity of hydroalcoholic extract from Lampaya medicinalis Phil in rats Biol. Res.
Morales,Glauco; Paredes,Adrián; Olivares,Alberto; Bravo,Jaime.
BACKGROUND: Algesia and inflammation are related with several pathological conditions. It is known that many drugs available for the treatment of these problems cause unwanted side effects. This study was aimed at evaluating acute toxicity and anti-inflammatory activity of Lampaya medicinalis Phil. (Verbenaceae) widely used in the folk medicine of Northern Chile against rheumatism, arthritis and body joints pain. RESULTS: Oral administration of hydroalcoholic extract (HAE) at the highest dose of 3000 mg/ Kg body weight resulted in no mortalities or evidence of significant behavioral changes. Histological examination revealed normal architecture and no significant adverse effects were observed on the liver, kidney, heart, lung or ovaries and testicles. The...
Tipo: Journal article Palavras-chave: Lampaya medicinalis; Hydroalcoholic extract; Acute oral toxicity; Histology; Hematology; Anti-inflammatory; Carrageenan.
Ano: 2014 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100006
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Octopus mimus (MOLLUSCA: CEPHALOPODA) EMBRYO MISDEVELOPMENT DUE TO CHRONIC EXPOSURE TO THE ORGANOSPHOSPHORUS PESTICICE PARATHON International Journal of Morphology
Gutiérrez-Pajares,Jorge L.; Olivares,Alberto; Bustos-Obregón,Eduardo.
Pesticides are of ample worldwide use. At present there is a growing concern about seawater contamination by these chemicals. Developing aquatic organisms are particularly at risk. For this reason, early development of Octopus mimus embryos under exposure to commercial Parathion was examined. Concentrations over 0.4 mM of the pesticide altered formation of the embryonic disc at the blastula stage, resulting in abnormal gastrulation and arrest of further development. This toxic effect may be due to the blockade of DNA synthesis elicited by organophosphoric pesticides causing diminished number of blastodermic cells at the time of epiboly, thus hindering the start of invagination. Seawater contamination seems, therefore, of relevance for survival of exposed...
Tipo: Journal article Palavras-chave: Octopus mimus; Parathion; Early embryo development.
Ano: 2003 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022003000300011
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